Homologous ribosomal proteins in bacteria, yeast, and humans. | Zendy

In-Jay Chen | Zendy; Aparna Dixit | Zendy; Douglas D. Rhoads | Zendy; Donald J. Roufa | Zendy

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Homologous ribosomal proteins in bacteria, yeast, and humans.

Author(s) -

In-Jay Chen,

Aparna Dixit,

Douglas D. Rhoads,

Donald J. Roufa

Publication year - 1986

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.83.18.6907

Subject(s) - biology , ribosomal protein , genetics , gene , ribosomal rna , ribosomal dna , ribosome , yeast , phylogenetic tree , rna

We describe sequences of two human ribosomal proteins, S14 and S17, and messenger RNAs that encode them. cDNAs were used as molecular hybridization probes to recognize complementary genes in rodent, Drosophila, and yeast chromosomal DNAs. Human ribosomal protein sequences are compared to analogous Chinese hamster, yeast, and bacterial genes. Our observations suggest that some ribosomal protein genes have been conserved stringently in the several phylogenetic lines examined. These genes apparently were established early in evolution and encode products that are fundamental to the translational apparatus. Other ribosomal protein genes examined, although similar enough to heterologous DNA sequences to indicate their structural relationships, appear to have diverged substantially during evolution, probably reflecting adaptations to different genetic environments.

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