Recombinant murine retroviruses containing avian v-myc induce a wide spectrum of neoplasms in newborn mice. | Zendy

Herbert C. Morse | Zendy; Janet W. Hartley | Zendy; T. N. Fredrickson | Zendy; R A Yetter | Zendy; C. Majumdar | Zendy; John L. Cleveland | Zendy; Ulf R. Rapp | Zendy

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Recombinant murine retroviruses containing avian v-myc induce a wide spectrum of neoplasms in newborn mice.

Author(s) -

Herbert C. Morse,

Janet W. Hartley,

T. N. Fredrickson,

R A Yetter,

C. Majumdar,

John L. Cleveland,

Ulf R. Rapp

Publication year - 1986

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.83.18.6868

Subject(s) - biology , recombinant dna , virology , murine leukemia virus , cancer research , cell culture , oncogene , haematopoiesis , leukemia , microbiology and biotechnology , b cell , in vitro , cell , gene , virus , immunology , genetics , stem cell , antibody , cell cycle

NFS/N mice were infected within 48 hr of birth with pseudotypes of recombinant murine leukemia viruses containing avian v-myc developed T-cell, pre-B-cell, and B-cell lymphomas and epithelial tumors including pancreatic and mammary adenocarcinomas. Primary hematopoietic and epithelial tumors and continuous in vitro cell lines derived from some of these tumors, established in the absence of added growth factors, exhibited clonal integrations of v-myc and expressed v-myc RNA. These results show that deregulated expression of the myc oncogene in mammalian cells can initiate a wide variety of neoplasms.

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