Open AccessSynthesis of coenzyme A ester of retinoic acid: intermediate in vitamin A metabolism.
Author(s) -
Andrzej Kutner,
Britta Renstrøm,
Heinrich K. Schnoes,
H. F. DeLuca
Publication year - 1986
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.83.18.6781
Subject(s) - coenzyme a , retinoic acid , cofactor , metabolism , chemistry , biochemistry , vitamin , pantothenic acid , chromatography , stereochemistry , enzyme , reductase , gene
Coenzyme A esters of all-trans- and 13-cis-retinoic acid were synthesized for use in studying vitamin A metabolism. The esters were obtained by two different synthetic methods starting from retinoic acids, which were converted to activated succinimidyl esters or anhydrides. These in turn were coupled with coenzyme A to form their respective thioesters. The retinoyl coenzyme A esters were purified by reverse-phase high performance liquid chromatography.
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