Open AccessExpression of a mouse long terminal repeat is cell cycle-linked.
Author(s) -
Leonard H. Augenlicht,
Heidi Halsey
Publication year - 1985
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.82.7.1946
Subject(s) - biology , long terminal repeat , elutriation , hamster , cell cycle , microbiology and biotechnology , homology (biology) , genome , genetics , cell , gene , chemistry , organic chemistry
The expression of the long terminal repeat (LTR) of intracisternal A particle retroviral sequences which are endogenous to the mouse genome has been shown to be linked to the early G1 phase of the cell cycle in Friend erythroleukemia cells synchronized by density arrest and also in logarithmically growing cells fractionated into cell-cycle compartments by centrifugal elutriation. Regions of homology were found in comparing the LTR sequence to a repetitive Syrian hamster sequence specifically expressed in early G1 in hamster cells.