Open AccessNeuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related.
Author(s) -
Caine W. Wong,
Vito Quaranta,
George G. Glenner
Publication year - 1985
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.82.24.8729
Subject(s) - senile plaques , amyloid (mycology) , pathogenesis , alzheimer's disease , beta (programming language) , biochemistry of alzheimer's disease , pathology , p3 peptide , amyloid beta , bace1 as , amyloid precursor protein , peptide , biology , chemistry , medicine , biochemistry , disease , computer science , programming language
A synthetic peptide (Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr), homologous to the amino terminus of a protein purified from cerebrovascular amyloid (beta protein), induced antibodies in BALB/c mice that were used immunohistochemically to stain not only amyloid-laden cerebral vessels but neuritic plaques as well. These findings suggest that the amyloid in neuritic plaques shares antigenic determinants with beta protein of cerebral vessels. Since the amino acid compositions of plaque amyloid and cerebrovascular amyloid are similar, it is likely that plaque amyloid also consists of beta protein. This possibility suggests a model for the pathogenesis of Alzheimer disease involving beta protein.