Identification of a unique B-cell-stimulating factor produced by a cloned dendritic cell. | Zendy

Carol Clayberger | Zendy; Rosemarie H. DeKruyff | Zendy; R Fay | Zendy; Harvey Cantor | Zendy

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Identification of a unique B-cell-stimulating factor produced by a cloned dendritic cell.

Author(s) -

Carol Clayberger,

Rosemarie H. DeKruyff,

R Fay,

Harvey Cantor

Publication year - 1985

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.82.1.183

Subject(s) - clone (java method) , biology , cell , b cell , lymphokine , microbiology and biotechnology , cell type , cloning (programming) , polyclonal antibodies , polyclonal b cell response , antigen , immunology , genetics , antibody , gene , b cell receptor , computer science , programming language

We describe a cloned dendritic cell, clone Den-1, which is a potent accessory cell for some B-cell responses. Clone Den-1 produces a unique lymphokine that induces polyclonal B-cell proliferation in the absence of other costimulators. This clone or factors produced by it also stimulate purified B cells to develop plaque-forming cell responses to type 2 antigens. The effect of this factor(s) on various B-cell populations and its relationship to previously described B-cell-stimulating factors is discussed.

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