Open AccessIdentification of a unique B-cell-stimulating factor produced by a cloned dendritic cell.
Author(s) -
Carol Clayberger,
Rosemarie H. DeKruyff,
Randi Fay,
Harvey Cantor
Publication year - 1985
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.82.1.183
Subject(s) - clone (java method) , biology , cell , b cell , lymphokine , microbiology and biotechnology , cell type , cloning (programming) , polyclonal antibodies , polyclonal b cell response , antigen , immunology , genetics , antibody , gene , b cell receptor , computer science , programming language
We describe a cloned dendritic cell, clone Den-1, which is a potent accessory cell for some B-cell responses. Clone Den-1 produces a unique lymphokine that induces polyclonal B-cell proliferation in the absence of other costimulators. This clone or factors produced by it also stimulate purified B cells to develop plaque-forming cell responses to type 2 antigens. The effect of this factor(s) on various B-cell populations and its relationship to previously described B-cell-stimulating factors is discussed.