Open AccessProviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas.
Author(s) -
David L. Steffen
Publication year - 1984
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.81.7.2097
Subject(s) - insertional mutagenesis , biology , murine leukemia virus , leukemia , virology , virus , lymphoma , proto oncogene proteins c myc , mutagenesis , proto oncogenes , cancer research , microbiology and biotechnology , gene , mutation , genetics , genome , immunology , regulation of gene expression , oncogene , cell cycle
Sixty-one murine leukemia virus-induced lymphomas were examined for evidence of proviral insertions adjacent to known oncogenes. Five of these lymphomas were found to have alterations adjacent to c-myc. Two of the lymphomas with altered c-myc sequences were examined in detail. Evidence was obtained showing that the alterations in the c-myc sequences in these two lymphomas were the result of proviral integrations. This result suggests that lymphomagenesis by murine leukemia viruses can result from insertional mutagenesis of cellular oncogenes.