Open AccessShared idiotopes among monoclonal antibodies specific for A/PR/8/34 (H1N1) and X-31(H3N2) influenza viruses.
Author(s) -
Thomas M. Moran,
YungNan C. Liu,
Jerome L. Schulman,
Constantin A. Bona
Publication year - 1984
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.81.6.1809
Subject(s) - idiotopes , monoclonal antibody , virology , idiotype , biology , hemagglutinin (influenza) , antibody , virus , immunoglobulin idiotypes , influenza a virus , antigenic drift , immunology
A monoclonal antibody specific for the hemagglutinin (HA) of influenza A X-31 (H3N2) virus (X-31) was obtained during a fusion of spleen cells from a BALB/c mouse immunized with influenza A/PR/8/34 (H1N1) virus (PR8). This monoclonal antibody (Py206) shares crossreactive idiotopes expressed on several monoclonal antibodies specific for PR8 HA and X-31 HA as well as an individual idiotope shared with one monoclonal antibody specific for X-31 HA. The presence of shared idiotypy among antibodies of such diverse binding specificities may result from regulation by idiotype-specific T cells. In addition, the results suggest that, in contrast to the diversity of paratypes expressed, relatively few germ-line variable region genes may be used in the antibody response to influenza A virus antigens.