Open AccessAllelic inclusion in the pre-B-cell line 18-81.
Author(s) -
Matthias Wabl,
Gabriele Beck-Engeser,
Peter D. Burrows
Publication year - 1984
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.81.3.867
Subject(s) - allelic exclusion , allele , biology , inclusion (mineral) , genetics , cell , cell culture , inclusion bodies , virology , microbiology and biotechnology , gene , t cell , chemistry , immune system , t cell receptor , mineralogy , escherichia coli
In an Abelson-virus-transformed mouse lymphoid cell line with pre-B-cell characteristics, a few cells continuously produce heavy chains from both homologs. Each chain has a different variable region. These cells thereby exhibit allelic inclusion rather than allelic exclusion.