Open AccessInterferon induces pulmonary cysts in A2G mice.
Author(s) -
David Woodrow,
Jill Moss,
Ion Gresser
Publication year - 1984
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.81.24.7937
Subject(s) - interferon , biology , genotype , interferon beta , microbiology and biotechnology , medicine , endocrinology , virology , genetics , gene
Suckling A2G mice were treated for the first week of life with either partially purified or electrophoretically pure mouse alpha/beta interferon. All mice subsequently developed multiple large pulmonary cysts. The lesions were never found in interferon-treated Swiss mice and only very infrequently in interferon-treated BALB/c or F1 Swiss/A2G mice. These observations show that a brief exposure of suckling A2G mice to alpha/beta interferon can result in a severe disease that is determined by the mouse genotype.