Open AccessSalt-induced Z-A-Z transition sequence in the mixed ribo-deoxyribo copolymer poly(rG-dC) X poly(rG-dC).
Author(s) -
H. Wu,
Michael J. Behe
Publication year - 1984
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.81.23.7284
Subject(s) - polynucleotide , helix (gastropod) , salt (chemistry) , copolymer , polymer , crystallography , chemistry , conformational change , stereochemistry , salt solution , sequence (biology) , polymer chemistry , biochemistry , organic chemistry , biology , ecology , snail
The left-handed helical conformation of various polynucleotides has been seen in solution at higher salt concentration than has the right-handed helical conformation of the corresponding polymer. We report here, however, studies of conformational transitions in the mixed polymer poly-(rG-dC) X poly(rG-dC). This polynucleotide appears to exist in a Z conformation under low-salt conditions, converts to an A helix at intermediate salt, and reverts to a left-handed helix at high-salt concentration.