Open AccessSynthesis and biological activity of human inhibin-like peptide-(1-31).
Author(s) -
Donald Yamashiro,
Choh Hao Li,
K. Ramasharma,
M.R. Sairam
Publication year - 1984
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.81.17.5399
Subject(s) - peptide , in vivo , biological activity , homogeneous , chemistry , in vitro , peptide hormone , amino acid , hormone , biochemistry , peptide synthesis , natural product , incubation , pituitary gland , biology , chromatography , physics , microbiology and biotechnology , thermodynamics
A peptide containing 31 amino acids with inhibin-like activity has been synthesized by the solid-phase method. The synthetic product was shown to be homogeneous in high-performance liquid chromatography and paper electrophoresis. In the mouse pituitary incubation system, the follitropin-suppressing activity of the synthetic peptide was comparable to that of the natural product. It was also active in suppressing lutropin-releasing hormone-induced follitropin release in vivo in immature male rats.