Open AccessInternal complementarities in the immune system: regulation of the expression of helper T-cell idiotypes.
Author(s) -
Carmen Martı́nez,
Pablo Pereira,
Rosa R. Bernabé,
A. Bandeira,
EvaLotta Larsson,
PierreAndré Cazenave,
Antönio Coutinho
Publication year - 1984
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.81.14.4520
Subject(s) - antibody , idiotype , biology , microbiology and biotechnology , immune system , monoclonal antibody , antigen , spleen , t helper cell , b cell , immunoglobulin idiotypes , immunology , t cell
More than half of BALB/c helper T lymphocytes specific for 2,4,6-trinitrophenyl (TNP)-modified syngeneic spleen cells are inhibited in their proliferative responses to antigen-presenting cells and in their cooperation with B lymphocytes by monoclonal anti-idiotypic antibodies directed to a TNP-binding BALB/c myeloma protein (MOPC 460). This inhibition is specific for anti-TNP-self helper cells of BALB/c origin and is controlled by IgCh-linked genes, as it is not observed with CB.20 helper cells of the same specificity. In contrast, anti-TNP-self helper cells prepared from BALB/c mice that were chronically suppressed with anti-mu chain antibodies and possessed no B lymphocytes were not inhibited by anti-idiotypic antibodies. We conclude that the B-cell antibody repertoires contribute to the selection of the (idiotypic) T-helper-cell repertoires.