Open AccessThe mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: macrophages of endocrine organs.
Author(s) -
David Hume,
David Halpin,
H. M. Charlton,
Siamon Gordon
Publication year - 1984
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.81.13.4174
Subject(s) - mononuclear phagocyte system , immunohistochemistry , endocrine system , luteolysis , pathology , corpus luteum , macrophage , biology , antigen , anterior pituitary , enteroendocrine cell , endocrine gland , endocrinology , medicine , ovary , hormone , immunology , biochemistry , in vitro
Macrophages of endocrine organs have been identified by immunohistochemical localization of the macrophage-specific antigen F4/80. F4/80+ cells line vascular sinuses and capillaries in anterior and posterior pituitary, adrenal cortex, corpus luteum, parathyroid, pineal gland, and islets of Langerhans. In testis approximately 20% of interstitial cells are F4/80+. F4/80+ cells infiltrate corpus luteum in increased numbers during luteolysis.