Open AccessIllegitimate recombination generates a class switch from C mu to C delta in an IgD-secreting plasmacytoma.
Author(s) -
A C Gilliam,
Anna L. Shen,
Julia E. Richards,
Frederick R. Blattner,
J. Frederic Mushinski,
Philip W. Tucker
Publication year - 1984
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.81.13.4164
Subject(s) - immunoglobulin d , recombination , plasmacytoma , microbiology and biotechnology , v(d)j recombination , immunoglobulin light chain , homology (biology) , immunoglobulin class switching , biology , immunoglobulin heavy chain , genetics , antibody , recombination signal sequences , gene , multiple myeloma , recombination activating gene , immunology , b cell
We present here the sequence characterization of a C mu----C delta immunoglobulin (Ig) heavy chain class switch. In the murine IgD-secreting plasmacytoma TEPC 1017, deletion of most of the mu switch recombination region (S mu) and the entire C mu gene occurred in the absence of switch region sequences 5' to C delta. This unique rearrangement resulted from an illegitimate recombination of sequences with only patchy homology to each other. The infrequent and variable nature of illegitimate recombination may explain the low frequency of IgD-secreting plasma cells in normal mouse tissues.