Open AccessEffects of tetracaine on charge movements and calcium signals in frog skeletal muscle fibers
Author(s) -
Julio L. Vergara,
Carlo Caputo
Publication year - 1983
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.80.5.1477
Subject(s) - tetracaine , calcium , skeletal muscle fibers , biophysics , skeletal muscle , chemistry , absorbance , grenouille , anatomy , biochemistry , biology , chromatography , neuroscience , salientia , lidocaine , organic chemistry , xenopus , gene
Intramembrane charge movements in skeletal muscle fibers contain a tetracaine-sensitive component that can be isolated by the use of this drug. The time course and voltage dependence of this component, studied in relation to antipyrylazo III absorbance signals, suggest its direct involvement in the calcium release process in muscle.