The PHI (PHI-27)/corticotropin-releasing factor/enkephalin immunoreactive hypothalamic neuron: possible morphological basis for integrated control of prolactin, corticotropin, and growth hormone secretion. | Zendy

Tomas Hökfelt | Zendy; Jan Fahrenkrug | Zendy; Kazuhiko Tatemoto | Zendy; V. Mutt | Zendy; Sigbritt Werner | Zendy; A.-L. Hulting | Zendy; Lars Terenius | Zendy; K J Chang | Zendy

Open Access

The PHI (PHI-27)/corticotropin-releasing factor/enkephalin immunoreactive hypothalamic neuron: possible morphological basis for integrated control of prolactin, corticotropin, and growth hormone secretion.

Author(s) -

Tomas Hökfelt,

Jan Fahrenkrug,

Kazuhiko Tatemoto,

V. Mutt,

Sigbritt Werner,

A.-L. Hulting,

Lars Terenius,

K J Chang

Publication year - 1983

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.80.3.895

Subject(s) - medicine , endocrinology , median eminence , prolactin , anterior pituitary , parvocellular cell , corticotropic cell , secretion , biology , corticotropin releasing hormone , enkephalin , hormone , hypothalamus , chemistry , receptor , opioid

By using the indirect immunofluorescence technique, one and the same neuron in the parvocellular part of the paraventricular nucleus has been shown to stain with antisera against three different peptides: PHI (PHI-27), corticotropin-releasing factor (CRF), and enkephalin. This could explain the well-known parallel increase in plasma prolactin, corticotropin, and growth hormone levels--for example, under certain types of stress--as being due to a concomitant release of PHI-like, CRF-like, and enkephalin-like peptides from the same nerve endings in the median eminence. A hypothetical mechanism for the co-ordinated release of these three anterior pituitary hormones is discussed.

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