H-2-linked regulation of xenotropic murine leukemia virus expression. | Zendy

R A Yetter | Zendy; Janet W. Hartley | Zendy; Herbert C. Morse | Zendy

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H-2-linked regulation of xenotropic murine leukemia virus expression.

Author(s) -

R A Yetter,

Janet W. Hartley,

Herbert C. Morse

Publication year - 1983

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.80.2.505

Subject(s) - locus (genetics) , biology , microbiology and biotechnology , murine leukemia virus , virus , phenotype , centimorgan , rickettsia , c57bl/6 , virology , glycoprotein , gene , chromosome , genetics , gene mapping , immunology

A high proportion of lymphocytes from F/St mice produce infectious xenotropic murine leukemia virus (X-MuLV) and express high levels of cell surface antigens, termed XenCSA, related to the major glycoprotein of X-MuLV. In crosses of F/St with AKR, the high-virus phenotype of F/St was found to be recessive and was shown to be governed by a single locus, Cxv-1, less than 2 centimorgans from H-2K. The close association of Cxv-1 with the H-2 complex was confirmed by the observation that B10.F mice, congeneic for the H-2 region of F/St, expressed high levels of infectious X-MuLV and XenCSA, whereas C57BL/10 mice and other C57BL/10 H-2 congeneic strains did not. Studies of hybrid mice homozygous for Cxv-1s, but segregating for a chromosome 1 X-MuLV induction locus (V locus) of F/St, demonstrated that the high-virus phenotype of F/St was dependent on the interaction between Cxv-1 and the chromosome 1 V locus.

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