Open AccessFamilial cutaneous malignant melanoma: autosomal dominant trait possibly linked to the Rh locus.
Author(s) -
Mark H. Greene,
Lynn R. Goldin,
Wallace H. Clark,
Everett W. Lovrien,
Kenneth H. Kraemer,
Margaret A. Tucker,
David E. Elder,
Mary C. Fraser,
Shirley I. Rowe
Publication year - 1983
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.80.19.6071
Subject(s) - locus (genetics) , genetics , genetic linkage , biology , melanoma , trait , quantitative trait locus , gene , computer science , programming language
Segregation and linkage analyses were undertaken in families with multiple cases of cutaneous malignant melanoma (CMM) and a recently-described melanoma precursor, the dysplastic nevus syndrome (DNS). Clinical and laboratory data, including 23 genetic markers, were collected on 401 members of 14 high-risk kindreds. Pedigree analysis was compatible with an autosomal dominant mode of inheritance for the familial CMM trait. Although a similar model probably applies to the DNS trait as well, segregation analysis could not confirm the presence of a major locus. However, linkage analysis suggested that an autosomal dominant model was appropriate for the DNS, and that a DNS/CMM susceptibility gene may be located on the short arm of chromosome 1, within 30 map units of the Rh locus [maximum logarithm of odds (lod) score = 2.00].