Open AccessLeucinopine, a characteristic compound of some crown-gall tumors
Author(s) -
Chandong Chang,
Chong-Maw Chen,
Bruce R. Adams,
Barry M. Trost
Publication year - 1983
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.80.12.3573
Subject(s) - octopine , agrobacterium tumefaciens , ti plasmid , gall , stereochemistry , biology , rhizobiaceae , chemistry , bacteria , biochemistry , genetics , gene , botany , transformation (genetics) , symbiosis
An unusual compound has been found in crowngall tumors induced by those Agrobacterium tumefaciens strains that utilize neither octopine nor nopaline. The compound has been isolated and shown by proton and carbon-13 NMR spectroscopy and by synthesis to be N(2)-(1,3-dicarboxypropyl)-L-leucine, which also exists in a cyclized (i.e., lactam) form. This compound, which we name "leucinopine," was not detected in octopine tumors, nopaline tumors, or the tumors induced by A. tumefaciens strains 181 and EU6.