Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes. | Zendy

Diane Mathis | Zendy; C Benoist | Zendy; V E Williams | Zendy; Michael H. Kanter | Zendy; H O McDevitt | Zendy

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Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes.

Author(s) -

Diane Mathis,

C Benoist,

V E Williams,

Michael H. Kanter,

H O McDevitt

Publication year - 1983

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.80.1.273

Subject(s) - haplotype , biology , major histocompatibility complex , gene , alpha (finance) , rna , microbiology and biotechnology , messenger rna , genetics , antigen , gene expression , genotype , medicine , construct validity , nursing , patient satisfaction

The murine Ia antigens, encoded by the I region of the major histocompatibility complex, are cell-surface glyco-proteins (consisting of alpha and beta polypeptides) thought to be involved in the control of immune responsiveness. Mice of haplotypes b, s, q, and f fail to express one of the Ia antigen complexes, the E complex, on the cell surface. We have attempted to determine at the molecular level how such a defect (or defects) might be generated. By using I-region E alpha and A alpha gene probes for analyses of RNA and DNA structure, it was possible to conclude that at least three mechanisms can operate. Mice of haplotypes b and s bear a deletion in the E alpha gene, f haplotype mice synthesize predominantly an E alpha mRNA of aberrant size, and mice of the q haplotype seem to have a defect in RNA processing or a problem with mRNA stability, or both.

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