Developmental regulation of mRNA in mouse heart. | Zendy

André J. Ouellette | Zendy; Dorothy E. Croall | Zendy; J Van Ness | Zendy; Joanne S. Ingwall | Zendy

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Developmental regulation of mRNA in mouse heart.

Author(s) -

André J. Ouellette,

Dorothy E. Croall,

J Van Ness,

Joanne S. Ingwall

Publication year - 1983

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.80.1.223

Subject(s) - tropomyosin , messenger rna , translation (biology) , biology , methionine , fetus , microbiology and biotechnology , myosin , protein biosynthesis , actin , heart development , biochemistry , amino acid , gene , embryonic stem cell , genetics , pregnancy

The myocardium contains abundant translatable mRNAs that change during development. Maximal cell-free synthesis of [3H]leucine-, [35S]methionine-, and [35S]cysteine-labeled translation products directed by poly(A)-containing mRNAs from 12-, 14-, and 17-day fetal; 5-day-old neonatal; and 30-day-old adult mouse heart was determined by using one- and two-dimensional polyacrylamide gels. Three general developmental patterns of heart-specific mRNA translation products were observed: two translatable mRNAs were most abundant in 12-day fetal heart; five mRNAs were most abundant in 14- and 17-day fetal heart and occurred only at low concentrations in 12-day fetal and adult heart; four mRNAs, including mRNAs coding for actin, tropomyosin, and myosin light chains 1 and 2, were most abundant in the adult heart. Thus, differentiating cardiac muscle is characterized by a complex pattern of mRNA regulation.

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