Open AccessViral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase.
Author(s) -
Wia C. Barker,
M. O. Dayhoff
Publication year - 1982
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.79.9.2836
Subject(s) - protein kinase a , biology , sh3 domain , map3k7 , c raf , autophagy related protein 13 , rous sarcoma virus , protein kinase r , proto oncogene tyrosine protein kinase src , cyclin dependent kinase 2 , map2k7 , protein superfamily , mitogen activated protein kinase kinase , biochemistry , gene , kinase , microbiology and biotechnology
The transforming protein sequences translated from the Rous avian and Moloney murine sarcoma virus src genes are shown to be related to the catalytic chain of bovine cAMP-dependent protein kinase (ATP:protein phosphotransferase, EC 2.7.1.37). The avian transforming protein, also a protein kinase, shows greatest homology with the bovine protein kinase in the carboxyl-terminal half, where the protein kinase activity is localized. Moreover, lysine occurs in the inferred transforming protein sequences at the position homologous with the proposed ATP-binding lysine of the bovine protein kinase. This relationship is consistent with the hypothesis that the src genes originated in the host genomes, in which they are members of a superfamily of distantly related protein kinases that are normal constituents of mammalian cells. In the host, these sequences are much more highly conserved than in the viruses.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom