Open AccessNerve growth factor: activation of the classical complement pathway by specific substitution for component C1-.
Author(s) -
Michael D. P. Boyle,
Michael Young
Publication year - 1982
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.79.8.2519
Subject(s) - nerve growth factor , zymogen , classical complement pathway , complement factor b , alternative complement pathway , complement system , chemistry , cleavage (geology) , complement (music) , homogeneous , contraction (grammar) , complement factor i , biochemistry , microbiology and biotechnology , enzyme , biology , endocrinology , antibody , immunology , receptor , phenotype , paleontology , physics , complementation , fracture (geology) , gene , thermodynamics
The interaction of homogeneous preparations of mouse submandibular gland nerve growth factor (NGF) with the classical complement pathway was studied. NGF was found to be capable of carrying out the enzyme activities of the first component (C1-) of the classical complement pathway (i.e., the cleavage of zymogen C4 and C2). NGF would not substitute for any other classical pathway component, C2-C9. The C1(-)-like activity of NGF was inhibited by human C1- inactivator. This interaction of NGF with the complement system may account for the previously described ability of NGF to accelerate the rate of contraction of experimentally induced wounds.