Exon/intron organization and complete nucleotide sequence of an HLA gene. | Zendy

Marie Malissen | Zendy; Bernard Malissen | Zendy; B.R. Jordan | Zendy

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Exon/intron organization and complete nucleotide sequence of an HLA gene.

Author(s) -

Marie Malissen,

Bernard Malissen,

B.R. Jordan

Publication year - 1982

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.79.3.893

Subject(s) - exon , tandem exon duplication , intron , gene , biology , genetics , exon shuffling , human leukocyte antigen , exon trapping , signal peptide , nucleic acid sequence , microbiology and biotechnology , transmembrane protein , transplantation , sequence (biology) , peptide sequence , antigen , alternative splicing , receptor , medicine , surgery

We have isolated and determined the sequence of a genomic clone containing the gene for a human class I transplantation antigen. The gene contains seven exons. The first five exons code respectively for a signal peptide, for the first, second, and third extracellular domains of the protein molecule, and for the transmembrane region. The cytoplasmic segment is encoded by part of the fifth and the sixth and the seventh exons. The structure of the protein encoded by this unit is closely homologous with known class I transplantation antigens.

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