Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization | Zendy

Jeffrey M. Trent | Zendy; Sharon Olson | Zendy; Richard M. Lawn | Zendy

Open Access

Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization

Author(s) -

Jeffrey M. Trent,

Sharon Olson,

Richard M. Lawn

Publication year - 1982

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.79.24.7809

Subject(s) - microbiology and biotechnology , biology , gene , interferon , chromosome , metaphase , plasmid , in situ hybridization , complementary dna , chromosome 15 , immune system , alpha interferon , recombinant dna , interferon gamma , fibroblast , chromosome 12 , genetics , cell culture , gene expression

Recombinant plasmids containing cDNA inserts from human leukocyte interferon (IFN-α), fibroblast interferon (IFN-β), or immune interferon (INF-γ) genes were radiolabeled and hybridizedin situ to human metaphase chromosome preparations. The results localized the human IFN-α and IFN-β genes to the short arm of chromosome 9(p21→pter) and localized the IFN-γ gene to the long arm of chromosome 12(q24.1).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research