Open AccessEffect of a conjugate of daunomycin and antibodies to rat alpha-fetoprotein on the growth of alpha-fetoprotein-producing tumor cells.
Author(s) -
Yutaka Tsutsumi,
Wolfgang Bischof,
Nozomu Hibi,
Hidematsu Hirai,
Esther Hurwitz,
Michael Sela
Publication year - 1982
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.79.2.621
Subject(s) - conjugate , antibody , alpha fetoprotein , cytotoxicity , alpha (finance) , chemistry , microbiology and biotechnology , biochemistry , biology , cancer research , immunology , medicine , in vitro , mathematical analysis , construct validity , mathematics , nursing , patient satisfaction , hepatocellular carcinoma
Daunomycin was covalently attached via a dextran bridge to specific antibodies against rat alpha-fetoprotein produced in a horse. The effect of this conjugate on an alpha-fetoprotein-producing tumor was investigated in terms of cytotoxicity and inhibition or retardation of tumor development. Under the experimental conditions used, the covalent conjugate was by both criteria more efficient than either daunomycin alone or a mixture of daunomycin and specific antibodies or a conjugate of daunomycin with horse immunoglobulin. These results show that the conjugate may be useful as a specific cytotoxic agent against alpha-fetoprotein-producing tumors.