Open AccessInverted repeat nucleotide sequences in the genomes of Marek disease virus and the herpesvirus of the turkey.
Author(s) -
José María Fernández Cebrián,
Christine Kaschka-Dierich,
Nicole Berthelot,
P Sheldrick
Publication year - 1982
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.79.2.555
Subject(s) - biology , virology , virus , genome , nucleic acid sequence , marek's disease , herpes simplex virus , dna , herpesviridae , genetics , gene , viral disease
The DNAs of two herpesvirus, the oncogenic Marek disease virus and the serologically related herpesvirus of the turkey, were studied by electron microscopy. On the basis of fold-back molecules observed in single-stranded DNA from both viruses, structures have been derived from the overall nucleotide sequence arrangement in their genomes. Although differing in molecular weight, the genomes of Marek disease virus and turkey herpesvirus are both constructed according to the same plan--two regions of unique nucleotide sequence, each enclosed by inverted repeat sequence. The genome structure of these viruses therefore closely resembles that of herpes simplex virus rather than the biologically more similar herpesvirus Epstein--Barr virus, H. saimiri, and H. ateles.