Open AccessA scanning calorimetric study of small molecule-lipid bilayer mixtures.
Author(s) -
Julian M. Sturtevant
Publication year - 1982
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.79.13.3963
Subject(s) - differential scanning calorimetry , lipid bilayer , bilayer , molecule , calorimetry , chemistry , phase transition , phosphatidylcholine , lipid bilayer phase behavior , phase (matter) , heat capacity , analytical chemistry (journal) , thermodynamics , materials science , chemical physics , crystallography , chromatography , organic chemistry , membrane , phospholipid , biochemistry , physics
The influence of small molecules on the main phase transition of dimyristoyl phosphatidylcholine was observed by high-sensitivity differential scanning calorimetry. The variation with temperature of the excess heat capacity is markedly affected by solid solution formation, which appears to be of frequent occurrence in solutions in lipid bilayers. The experimental results are in some cases in reasonable agreement with ideal solution theory.