Open AccessNMR chemical shift imaging in three dimensions.
Author(s) -
Truman R. Brown,
B. M. Kincaid,
Kâmil Uğurbil
Publication year - 1982
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.79.11.3523
Subject(s) - fourier transform , pulse sequence , fourier analysis , nuclear magnetic resonance , chemistry , analytical chemistry (journal) , physics , mathematics , mathematical analysis , chromatography
A method for obtaining the three-dimensional distribution of chemical shifts in a spatially inhomogeneous sample using Fourier transform NMR is presented. The method uses a sequence of pulsed field gradients to measure the Fourier transform of the desired distribution on a rectangular grid in (k,t) space. Simple Fourier inversion then recovers the original distribution. An estimated signal/noise ratio of 20 in 10 min is obtained for an "image" of the distribution of a 10 mM phosphorylated metabolite in the human head at a field of 20 kG with 2-cm resolution.