Is acquired immunological tolerance genetically transmissible? | Zendy

Eric NisbetBrown | Zendy; T Wegmann | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Is acquired immunological tolerance genetically transmissible?

Author(s) -

Eric NisbetBrown,

T Wegmann

Publication year - 1981

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.78.9.5826

Subject(s) - biology , immune tolerance , immunology , histocompatibility , antigen , germline , major histocompatibility complex , genetics , gene , human leukocyte antigen

We have attempted to verify that acquired characteristics can be transmitted through the male germ line by using as a model system the vertical transmission of specific immunological tolerance to major histocompatibility antigens. Tolerant males were a tetraparental mouse and separated parabionts, in each case showing stable lymphoid chimerism. Tolerance in the progeny was assessed by two in vivo assays, rejection of cardiac allografts and clearance of 131I-labeled tumor cells. We were unable to find evidence for heritability of the tolerant state in tetraparental or parabiont males, with either assay system.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research