Open AccessProlongation of murine islet allograft survival by pretreatment of islets with antibody directed to Ia determinants.
Author(s) -
Denise L. Faustman,
Vëra Hauptfeld,
Paul E. Lacy,
Joseph M. Davie
Publication year - 1981
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.78.8.5156
Subject(s) - islet , immunosuppression , transplantation , splenocyte , immunology , immune system , major histocompatibility complex , histocompatibility , immune tolerance , antibody , graft rejection , medicine , biology , antigen , human leukocyte antigen , diabetes mellitus , endocrinology
Islets of Langerhans treated with donor-specific anti-Ia serum and complement were transplanted across a major histocompatibility barrier into nonimmunosuppressed diabetic mice. The allografts survived in all recipients for at least 200 days after transplantation. Rejection of an established allograft could be induced by intravenous injection of donor splenocytes. This demonstrates that allografts can serve as targets for immune rejection and supports the possible role of Ia-positive passenger lymphoid cells in initiation of immune rejection. The results show that immunosuppression of the recipient is not a prerequisite for successful transplantation.