Open AccessDNA replication-mediated recombination of molecules of adenovirus 2 DNA.
Author(s) -
Debra J. Wolgemuth,
Ming Hsu
Publication year - 1981
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.78.8.5076
Subject(s) - recombination , nucleoprotein , dna , biology , genetic recombination , dna replication , hela , microbiology and biotechnology , molecule , genetics , chemistry , gene , cell culture , organic chemistry
Molecules of adenovirus 2 DNA were isolated as nucleoprotein complexes late in infection of HeLa cells and examined by electron microscopy. Some were interpreted as representing intermediates in recombination events. The structures observed were consistent with predicted intermediates according to the model for genetic recombination proposed by Meselson and Radding [Meselson, M. S. & Radding, C. M. (1975) Proc. Natl. Acad. Sci. USA 72, 358-361] and constitute physical evidence from animal cells in support of this model.