DNA replication-mediated recombination of molecules of adenovirus 2 DNA. | Zendy

Debra J. Wolgemuth | Zendy; M T Hsu | Zendy

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DNA replication-mediated recombination of molecules of adenovirus 2 DNA.

Author(s) -

Debra J. Wolgemuth,

M T Hsu

Publication year - 1981

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.78.8.5076

Subject(s) - recombination , nucleoprotein , dna , biology , genetic recombination , dna replication , hela , microbiology and biotechnology , molecule , genetics , chemistry , gene , cell culture , organic chemistry

Molecules of adenovirus 2 DNA were isolated as nucleoprotein complexes late in infection of HeLa cells and examined by electron microscopy. Some were interpreted as representing intermediates in recombination events. The structures observed were consistent with predicted intermediates according to the model for genetic recombination proposed by Meselson and Radding [Meselson, M. S. & Radding, C. M. (1975) Proc. Natl. Acad. Sci. USA 72, 358-361] and constitute physical evidence from animal cells in support of this model.

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