Theoretical aspects of translocation on DNA: adenosine triphosphatases and treadmilling binding proteins. | Zendy

Terrell L. Hill | Zendy; Tomohiro Tsuchiya | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Theoretical aspects of translocation on DNA: adenosine triphosphatases and treadmilling binding proteins.

Author(s) -

Terrell L. Hill,

Tomohiro Tsuchiya

Publication year - 1981

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.78.8.4796

Subject(s) - treadmilling , dna , dna replication , biophysics , helicase , biology , translocase , microbiology and biotechnology , atpase , actin , biochemistry , chemistry , chromosomal translocation , rna , enzyme , cytoskeleton , microfilament , cell , gene

The basic kinetic and bioenergetic theory is outlined for two kinds of translocation on DNA: (i) helicases that use ATP to move along single-stranded DNA or to move on and invade double-stranded DNA at a replication fork; and (ii) DNA-binding proteins (not ATPases) that form bound aggregates on single-stranded DNA and facilitate replication by steady-state treadmilling of molecules between the ends of the aggregate. The respective resemblances to myosin--actin in muscle and to steady-state treadmilling in solution of actin or tubulin are pointed out.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research