Indirect induction of mutagenesis of intact parvovirus H-1 in mammalian cells treated with UV light or with UV-irradiated H-1 or simian virus 40. | Zendy

Jan J. Cornelis | Zendy; Zhihang Su | Zendy; David C. Ward | Zendy; Jean Rommelaere | Zendy

Open Access

Indirect induction of mutagenesis of intact parvovirus H-1 in mammalian cells treated with UV light or with UV-irradiated H-1 or simian virus 40.

Author(s) -

Jan J. Cornelis,

Zhihang Su,

David C. Ward,

Jean Rommelaere

Publication year - 1981

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.78.7.4480

Subject(s) - mutagenesis , parvovirus , virus , biology , mutant , irradiation , microbiology and biotechnology , parvoviridae , virology , cell culture , simian , biochemistry , gene , genetics , physics , nuclear physics

The frequency of mutants among the descendants of intact parvovirus H-1 was increased when cells of human and rat origin were exposed to UV light prior to infection. An enhanced mutagenesis of intact H-1 could be induced to almost the same extent in unirradiated cells by preinfecting them with H-1 or simian virus 40 that had been irradiated with UV light. The expression of an enhanced mutagenesis of unirradiated H-1 after cell treatment with UV light or UV-irradiated virus was delayed, transient, and dose-dependent, and it was dependent on de novo protein synthesis.

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