Open AccessTranslational control of ribosomal protein L10 synthesis occurs prior to formation of first peptide bond
Author(s) -
Nikolaos K. Robakis,
Luís Meza-Basso,
Nathan Brot,
Herbert Weissbach
Publication year - 1981
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.78.7.4261
Subject(s) - peptide bond , dipeptide , ribosomal rna , protein biosynthesis , peptide , ribosomal protein , chemistry , peptide synthesis , ribosome , biology , microbiology and biotechnology , biochemistry , gene , rna
A simplified DNA-directedin vitro system has been developed to study the regulation of the synthesis of ribosomal protein L10 by measuring the formation of the first dipeptide, fMet-Ala. The results show that the inhibition of L10 synthesis by L10 (autoregulation) occurs at or prior to the formation of the first peptide bond.