Sequence homology between RNAs encoding rat alpha-fetoprotein and rat serum albumin. | Zendy

Leszek Jagodziński | Zendy; Thomas D. Sargent | Zendy; Mina Yang | Zendy; Carlotta A. Glackin | Zendy; James Bonner | Zendy

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Sequence homology between RNAs encoding rat alpha-fetoprotein and rat serum albumin.

Author(s) -

Leszek Jagodziński,

Thomas D. Sargent,

Mina Yang,

Carlotta A. Glackin,

James Bonner

Publication year - 1981

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.78.6.3521

Subject(s) - nucleic acid sequence , biology , microbiology and biotechnology , peptide sequence , complementary dna , homology (biology) , gene , serum albumin , amino acid , biochemistry

We have determined the sequences of the recombinant DNA inserts of three bacterial plasmid cDNA clones containing most of the rat alpha a-fetoprotein mRNA. The resultant nucleotide sequence of alpha-fetoprotein was exhaustively compared to the nucleotide sequence of the mRNA encoding rat serum albumin. These two mRNAs have extensive homology (50%) throughout and the same intron locations. The amino acid sequence of rat alpha-fetoprotein has been deduced from the nucleotide sequence, and its comparison to rat serum albumin's amino acid sequence reveals a 34% homology. The regularly spaced positions of the cysteines found in serum albumin are conserved in rat alpha-fetoprotein, indicating that these two proteins may have a similar secondary folding structure. These homologies indicate that alpha-fetoprotein and serum albumin were derived by duplication of a common ancestral gene and constitute a gene family.

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