Clinical applications of the radioimmunoassay of secretory tuberculoprotein.
Author(s) -
Eugene Straus,
Ning Wu,
Mashrura Quraishi,
Samuel C. Levine
Publication year - 1981
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.78.5.3214
Subject(s) - radioimmunoassay , mycobacterium tuberculosis , sputum , isoniazid , microbiology and biotechnology , in vitro , antibiotics , tuberculosis , mycobacterium , chemistry , medicine , biology , biochemistry , pathology
A radioimmunoassay that measures a specific secretory tuberculoprotein was used to detect Mycobacterium tuberculosis in 9 of 30 liquid cultures of sputum. The accumulation of immunoreactive material in liquid cultures containing isoniazid was shown to reflect in vitro susceptibility of mycobacteria to the antibiotic effects of the drug.
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