Open AccessTwo allelic forms of mouse beta 2-microglobulin.
Author(s) -
Peter Robinson,
Lynn Graf,
Karin Sege
Publication year - 1981
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.78.2.1167
Subject(s) - beta (programming language) , beta 2 microglobulin , histocompatibility , allele , biology , major histocompatibility complex , antigen , microbiology and biotechnology , genetics , isotype , heterozygote advantage , polyacrylamide gel electrophoresis , antibody , gene , human leukocyte antigen , immunology , biochemistry , enzyme , monoclonal antibody , computer science , programming language
Two allelic forms of mouse beta 2-microglobulin (beta 2m), the small polypeptide chain of H-2 histocompatibility antigens, have been identified. The two forms can be distinguished by NaDodSO4/polyacrylamide gel electrophoresis. All inbred mouse strains express a single beta 2m isotype. Mice heterozygous for beta 2m synthesize both forms, showing codominant expression of beta 2m alleles. In mice heterozygous for both H-2 and beta 3m, individual H-2 histocompatibility antigens associate with both beta 2m forms. Preliminary structural studies indicate differences in peptide composition between the two forms.