Open AccessEvidence that ribosomal protein S10 participates in control of transcription termination.
Author(s) -
David I. Friedman,
Alan T. Schauer,
M. R. Baumann,
L. S. Baron,
Sankar Adhya
Publication year - 1981
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.78.2.1115
Subject(s) - antitermination , ribosomal protein , transcription (linguistics) , biology , gene , lambda phage , gene product , microbiology and biotechnology , escherichia coli , genetics , ribosomal rna , gene expression , ribosome , bacteriophage , rna , linguistics , philosophy
We report the isolation of an Escherichia coli K-12 strain with a mutation, nusE71, that results in a change in ribosomal protein S10. Phage lambda fails to grow in hosts carrying the nusE71 mutation because the lambda N gene product is not active. The N product regulates phage gene expression by altering transcription complexes so that they can overcome termination barriers. This suggests that a ribosomal protein is involved in antitermination of transcription.