Interactions among iron(II) bleomycin, Lewis bases, and DNA. | Zendy

W.E. Antholine | Zendy; David H. Petering | Zendy; Leon A. Saryan | Zendy; Christine E. Brown | Zendy

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Interactions among iron(II) bleomycin, Lewis bases, and DNA.

Author(s) -

W.E. Antholine,

David H. Petering,

Leon A. Saryan,

Christine E. Brown

Publication year - 1981

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.78.12.7517

Subject(s) - dna , chemistry , bleomycin , stereochemistry , bond cleavage , glutathione , crystallography , biochemistry , biology , enzyme , genetics , chemotherapy , catalysis

The interaction of sulfur-containing ligands with complexes of Fe(II) bleomycin [Fe(II)Blm] was investigated by comparing DNA strand-scission activity with the structural characteristics of the complex. The bithiazole ring of excess Blm can form intermolecular complexes with Fe(II)Blm and with NO-Fe(II)Blm, and the bithiazole groups of CO-Fe(II)Blm interact with the metal center. This binding can be reversed by glutathione, CO-Fe(II)Blm binds to poly(dA-dT) . poly(dA-dT) via its bithiazole group to change the environment of the Fe2+ ion. Glutathione binds to the CO-Fe(II)Blm-poly(dA-dT) . poly(dA-dT) complex under conditions in which it stimulates DNA strand scission by Fe(II)Blm.

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