Electrical stimulation of sympathetic nerves increases the concentration of cyclic AMP in rat pineal gland. | Zendy

William E. Heydorn | Zendy; Alan Frazer | Zendy; Benjamin Weiss | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Electrical stimulation of sympathetic nerves increases the concentration of cyclic AMP in rat pineal gland.

Author(s) -

William E. Heydorn,

Alan Frazer,

Benjamin Weiss

Publication year - 1981

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.78.11.7176

Subject(s) - phentolamine , stimulation , bretylium , endocrinology , medicine , reserpine , postsynaptic potential , pineal gland , norepinephrine , chemistry , adrenergic receptor , stimulus (psychology) , adrenergic , receptor , biology , melatonin , dopamine , psychology , psychotherapist

Electrical stimulation of the superior cervical ganglia causes a rapid increase in the concentration of cyclic AMP in the pineal gland of rats. This effect is dependent upon the frequency, voltage, and duration of the stimulus and is markedly potentiated by pretreating the animals with desmethylimipramine. The increase in cyclic AMP is blocked by prior treatment of the rats with reserpine, bretylium, or propanolol but not with phentolamine. These results provide direct evidence that electrical stimulation of sympathetic nerves increases cyclic AMP in a target organ through the release of norepinephrine from presynaptic terminals acting on postsynaptic beta-adrenergic receptors.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research