Sequence-specific contacts between the RNA polymerase of vesicular stomatitis virus and the leader RNA gene. | Zendy

Jack D. Keene | Zendy; B J Thornton | Zendy; Suzanne U. Emerson | Zendy

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Sequence-specific contacts between the RNA polymerase of vesicular stomatitis virus and the leader RNA gene.

Author(s) -

Jack D. Keene,

B J Thornton,

Suzanne U. Emerson

Publication year - 1981

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.78.10.6191

Subject(s) - vesicular stomatitis virus , rna polymerase , biology , transcription (linguistics) , rna , rna dependent rna polymerase , microbiology and biotechnology , polymerase , virology , gene , vesicular stomatitis indiana virus , rna polymerase ii , genetics , virus , gene expression , promoter , linguistics , philosophy

Methylation-protection studies with nucleocapsids from vesicular stomatitis virus indicate that the viral polymerase (L and NS proteins) contacts the genomic RNA template in the middle of the leader gene, 16-30 nucleotides from the 3' terminus. The data suggest that the NS protein binds to the sequence (formula, see text) and may function as an initiator protein for transcription.

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