Open AccessAmino acid sequence of a human leukocyte interferon.
Author(s) -
Warren P. Levy,
Menachem Rubinstein,
John E. Shively,
U Del Valle,
ChunYen Lai,
John Moschera,
Larry Brink,
Louise Gerber,
Stanley Stein,
Sidney Pestka
Publication year - 1981
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.78.10.6186
Subject(s) - recombinant dna , peptide sequence , interferon , amino acid , dna , biology , sequence (biology) , protein primary structure , biochemistry , microbiology and biotechnology , genetics , gene
The primary structures of three major species of human leukocyte interferon differ from the structure predicted from the DNA sequence of recombinants containing leukocyte interferon-coding regions. Compared to the recombinant interferon produced in bacteria, three of the purified natural proteins isolated from leukocytes lack the 10 COOH-terminal amino acids suggested by the DNA sequence.