Biosynthesis of vitamin B12: identity of fragment extruded during ring contraction to the corrin macrocycle. | Zendy

Alan R. Battersby | Zendy; M J Bushell | Zendy; Christopher G. Jones | Zendy; Norman Lewis | Zendy; Anja Pfenninger | Zendy

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Biosynthesis of vitamin B12: identity of fragment extruded during ring contraction to the corrin macrocycle.

Author(s) -

Alan R. Battersby,

M J Bushell,

Christopher G. Jones,

Norman Lewis,

Anja Pfenninger

Publication year - 1981

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.78.1.13

Subject(s) - corrin , vitamin b12 , chemistry , stereochemistry , ring (chemistry) , acetic acid , biosynthesis , cyanocobalamin , contraction (grammar) , biochemistry , organic chemistry , biology , endocrinology , enzyme

Incorporation experiments with labeled sirohydrochlorin and trimethylisobacteriochlorin demonstrate that ring contraction in vivo to the corrin macrocycle of vitamin B12 liberates acetic acid. The C-20 atom of the precursors becomes the acetate carboxyl carbon.

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