Open AccessBiosynthesis of vitamin B12: nature of the volatile fragment generated during formation of the corrin ring system.
Author(s) -
Luisa Mombelli,
Cornelius Nussbaumer,
Hans Peter Weber,
Gerhard Müller,
D. Arigoni
Publication year - 1981
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.78.1.11
Subject(s) - corrin , vitamin b12 , chemistry , fragment (logic) , ligand (biochemistry) , ring (chemistry) , methylation , stereochemistry , acetic acid , biosynthesis , biochemistry , organic chemistry , receptor , dna , gene , computer science , programming language
It is shown with the help of radiolabeled substrates that biological formation of the corrin ligand system of cobyrinic acid is linked with the release of an equivalent of acetic acid from a hydroporphinoid precursor in which the C-20 atom has undergone methylation prior to its excision from the macrocycle.