Establishment of the interferon-mediated antiviral state: role of fatty acid cyclooxygenase. | Zendy

R Pottathil | Zendy; K A Chandrabose | Zendy; Pedro Cuatrecasas | Zendy; David J. Lang | Zendy

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Establishment of the interferon-mediated antiviral state: role of fatty acid cyclooxygenase.

Author(s) -

R Pottathil,

K A Chandrabose,

Pedro Cuatrecasas,

David J. Lang

Publication year - 1980

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.77.9.5437

Subject(s) - cyclooxygenase , interferon , chemistry , oxidoreductase , pharmacology , biochemistry , biology , enzyme , immunology

Inhibitors of fatty acid cyclooxygenase 8,11,14-icosatrienoate, hydrogen donor:oxygen oxidoreductase, EC 1.14.99.1) were found to suppress the establishment of the interferon-mediated antiviral state. The prevention, by these compounds, of the development of interferon protection correlated with the degree as well as the duration of cyclooxygenase inhibition. Anti-inflammatory substances lacking cyclooxygenase inhibitory activity did not interfere with the establishment of interferon protection. The addition of exogenous prostaglandins was not found to replace the need for a functional cyclooxygenase and, in some instances, could be shown to diminish the establishment of interferon protection. It is proposed that fatty acid cyclooxygenase is an essential component in the optimal induction of the interferon antiviral state.

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