The tetramer d(CpGpCpG) crystallizes as a left-handed double helix. | Zendy

James L. Crawford | Zendy; Francis J. Kolpak | Zendy; A H Wang | Zendy; Gary J. Quigley | Zendy; Jacques H. van Boom | Zendy; G. van der Marel | Zendy; Alexander Rich | Zendy

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The tetramer d(CpGpCpG) crystallizes as a left-handed double helix.

Author(s) -

James L. Crawford,

Francis J. Kolpak,

A H Wang,

Gary J. Quigley,

Jacques H. van Boom,

G. van der Marel,

Alexander Rich

Publication year - 1980

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.77.7.4016

Subject(s) - random hexamer , crystallography , tetramer , stacking , helix (gastropod) , crystal structure , molecule , chemistry , stereochemistry , cytosine , dna , biology , biochemistry , ecology , enzyme , organic chemistry , snail

The structure of the tetramer d(CpGpCpG) has been solved by x-ray analysis in two different crystal forms with and without spermine cations. The molecules crystallize in hexagonal unit cells and they form a left-handed double helix of Z-DNA similar to that previously reported for the hexamer d(CpGpCpGpCpG). In the crystal lattice the molecules stack together to form a virtually continuous left-handed double helix in which every fourth phosphate group is missing. The stacking of bases upon each other is similar to that seen in the hexamer. However, the base pairs have a slightly different orientation in that the cytosine residues are slightly removed from the axis of the molecule compared to the position they occupy in the hexamer. The structures are similar in two crystal forms with and without spermine cations.

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