Isolation, structure, biological characterization, and synthesis of beta-[Tyr9]melanotropin-(9-18) decapeptide from pig hypothalami. | Zendy

Andrew V. Schally | Zendy; Robert C. Chang | Zendy; Wei Huang | Zendy; D.H. Coy | Zendy; Abba J. Kastin | Zendy; Tommie W. Redding | Zendy

Open Access

Isolation, structure, biological characterization, and synthesis of beta-[Tyr9]melanotropin-(9-18) decapeptide from pig hypothalami.

Author(s) -

Andrew V. Schally,

Robert C. Chang,

Wei Huang,

D.H. Coy,

Abba J. Kastin,

Tommie W. Redding

Publication year - 1980

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.77.7.3947

Subject(s) - tetrapeptide , tyrosine , chemistry , amino acid , residue (chemistry) , prohormone , peptide sequence , histidine , peptide , stereochemistry , biochemistry , oligopeptide , biological activity , beta (programming language) , hormone , in vitro , gene , computer science , programming language

A decapeptide with the amino acid sequence H-Tyr-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp-OH was isolated from acid extracts of porcine hypothalami, structurally and biologically characterized, and synthesized. Except for the NH2-terminal tyrosine, this decapeptide corresponds to the amino acid sequences 9-18 of porcine beta-melanotropin (beta-MSH) and 49-58 of porcine beta-lipotropin (beta-LPH); it also has a tetrapeptide sequence of amino acids (Phe-Arg-Trp-Gly) common to the 7-10 sequences in corticotropin (ACTH) and alpha-MSH. beta-MSH, beta-LPH, alphaMSH, and ACTH from various species all have a histidine residue in the position immediately preceding the common sequence, and the occurrence of a natural peptide with the tyrosine residue in the corresponding site has not been previously reported. This suggests that the beta-[Tyr9]MSH-(9-18) decapeptide might be a fragment of a still larger precursor (prohormone) possibly related to beta-LPH.

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