Use of collagen-hydroxyethylmethacrylate hydrogels for cell growth. | Zendy

L Civerchia-Perez | Zendy; Barbara Faris | Zendy; Gisèle LaPointe | Zendy; John Beldekas | Zendy; Howard M. Leibowitz | Zendy; Carl Franzblau | Zendy

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Use of collagen-hydroxyethylmethacrylate hydrogels for cell growth.

Author(s) -

L Civerchia-Perez,

Barbara Faris,

Gisèle LaPointe,

John Beldekas,

Howard M. Leibowitz,

Carl Franzblau

Publication year - 1980

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.77.4.2064

Subject(s) - self healing hydrogels , adhesion , cell adhesion , cell growth , biophysics , chemistry , cell , monomer , polymer chemistry , biochemistry , biology , polymer , organic chemistry

Collagen-hydroxyethylmethacrylate hydrogels were prepared by polymerizing monomeric hydroxyethylmethacrylate in the presence of various concentrations of soluble native collagen. The resulting transparent hydrogels were evaluated as substrata for growth of IMR-90 human embryonic lung fibroblasts. Without collagen no significant growth occurred, whereas a dose-response curve expressing maximal cell growth against collagen concentration could be constructed quite readily by the use of appropriate hydrogels. The method allows for quantification of the collagen contribution to cell growth and, in a more general sense, provides the foundation for a relatively easy procedure to probe mechanisms of cell adhesion and cell differentiation.

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